FOXK2

FOXK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JXS, 2C6Y
Identifiers
Aliases	FOXK2, ILF, ILF-1, ILF1, forkhead box K2, nGTBP
External IDs	OMIM: 147685; MGI: 1916087; HomoloGene: 18748; GeneCards: FOXK2; OMA:FOXK2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	82,644,662 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	121,309,896 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; sural nerve; ; ganglionic eminence; ; oocyte; ; muscle of thigh; ; ventricular zone; ; left testis; ; right testis; ; gingival epithelium; ; sperm;
	Top expressed in
	zygote; ; secondary oocyte; ; cumulus cell; ; ventricular zone; ; ascending aorta; ; renal corpuscle; ; tail of embryo; ; otic vesicle; ; mandibular prominence; ; spermatocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; magnesium ion binding; metal ion binding; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription cis-regulatory region binding; DNA-binding transcription repressor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm; cytoplasm;
Biological process	regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; transcription, DNA-templated; transcription by RNA polymerase II; protein deubiquitination; anatomical structure morphogenesis; cell differentiation; negative regulation of transcription by RNA polymerase II; cellular glucose homeostasis; negative regulation of autophagy; regulation of glucose metabolic process; response to starvation; negative regulation of transcription, DNA-templated; positive regulation of transcription, DNA-templated; canonical glycolysis;
	Sources:Amigo / QuickGO
Orthologs
	3607
	68837
	ENSG00000141568
	ENSMUSG00000039275
	Q01167
	Q3UCQ1
	NM_004514; NM_181430; NM_181431
	NM_001080932; NM_001363033
	NP_004505
	NP_001074401; NP_001349962
	Wikidata
View/Edit Human	View/Edit Mouse

Forkhead box protein K2 is a protein that in humans is encoded by the FOXK2 gene.

The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements.