FLII

FLII
Identifiers
Aliases	FLII, FLI, FLIL, Fli1, actin remodeling protein, FLII actin remodeling protein
External IDs	OMIM: 600362; MGI: 1342286; HomoloGene: 11092; GeneCards: FLII; OMA:FLII - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	18,258,738 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	60,618,089 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; muscle of thigh; ; gastrocnemius muscle; ; skeletal muscle tissue; ; spleen; ; mucosa of transverse colon; ; pituitary gland; ; anterior pituitary; ; minor salivary glands; ; right lobe of thyroid gland;
	Top expressed in
	Ileal epithelium; ; choroid plexus of fourth ventricle; ; granulocyte; ; cardiac muscle tissue of left ventricle; ; lactiferous gland; ; tracheobronchial tree; ; internal carotid artery; ; mesenteric lymph nodes; ; right lung lobe; ; muscle of thigh;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	actin binding; protein binding; actin filament binding;
Cellular component	cell junction; cytoskeleton; brush border; nucleus; focal adhesion; nucleoplasm; microtubule organizing center; cytoplasm; cytosol;
Biological process	multicellular organism development; actin filament severing; regulation of transcription, DNA-templated; actin cytoskeleton organization; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	2314
	14248
	ENSG00000177731; ENSG00000284571
	ENSMUSG00000002812
	Q13045
	Q9JJ28
	NM_001256264; NM_001256265; NM_002018
	NM_022009; NM_001302207
	NP_001243193; NP_001243194; NP_002009
	NP_001289136; NP_071292
	Wikidata
View/Edit Human	View/Edit Mouse

Protein flightless-1 homolog is a protein that in humans is encoded by the FLII gene.

This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17.