FKBP1B

FKBP1B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1C9H, 3J8E, 4C02, 4IQ2, 4IQC
Identifiers
Aliases	FKBP1B, FKBP12.6, FKBP1L, OTK4, PKBP1L, PPIase, FK506 binding protein 1B, FKBP prolyl isomerase 1B
External IDs	OMIM: 600620; MGI: 1336205; HomoloGene: 68380; GeneCards: FKBP1B; OMA:FKBP1B - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	24,063,681 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	4,891,591 bp
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; caudate nucleus; ; putamen; ; hippocampus proper; ; anterior cingulate cortex; ; temporal lobe; ; Amygdala; ; dorsolateral prefrontal cortex; ; right frontal lobe; ; superior frontal gyrus;
	Top expressed in
	trigeminal ganglion; ; barrel cortex; ; spinal ganglia; ; islet of Langerhans; ; facial motor nucleus; ; lumbar spinal ganglion; ; motor neuron; ; substantia nigra; ; CA3 field; ; Medulla Oblongata;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	ryanodine-sensitive calcium-release channel activity; calcium channel inhibitor activity; transmembrane transporter binding; FK506 binding; isomerase activity; peptidyl-prolyl cis-trans isomerase activity; protein binding; signaling receptor binding; cyclic nucleotide binding;
Cellular component	cytoplasm; calcium channel complex; intracellular membrane-bounded organelle; membrane; sarcoplasmic reticulum; Z discdkac; sarcoplasmic reticulum membrane; cytosol;
Biological process	smooth muscle contraction; regulation of ryanodine-sensitive calcium-release channel activity; release of sequestered calcium ion into cytosol; regulation of cardiac conduction; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; regulation of cytosolic calcium ion concentration; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; positive regulation of cytosolic calcium ion concentration; cell communication by electrical coupling involved in cardiac conduction; negative regulation of insulin secretion involved in cellular response to glucose stimulus; insulin secretion; response to glucose; positive regulation of axon regeneration; protein maturation by protein folding; response to organic substance; negative regulation of heart rate; response to vitamin E; regulation of heart rate; negative regulation of ryanodine-sensitive calcium-release channel activity; response to redox state; T cell proliferation; ion transmembrane transport; positive regulation of sequestering of calcium ion; neuronal action potential propagation; protein refolding; negative regulation of release of sequestered calcium ion into cytosol; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; 'de novo' protein folding; calcium-mediated signaling using intracellular calcium source; response to hydrogen peroxide; chaperone-mediated protein folding; protein peptidyl-prolyl isomerization; negative regulation of phosphoprotein phosphatase activity;
	Sources:Amigo / QuickGO
Orthologs
	2281
	14226
	ENSG00000119782
	ENSMUSG00000020635
	P68106
	Q9Z2I2
	NM_004116; NM_054033; NM_001322963; NM_001322964
	NM_016863; NM_001378816; NM_001378817; NM_001378818
	NP_001309892; NP_001309893; NP_004107; NP_473374
	NP_058559; NP_001365745; NP_001365746; NP_001365747
	Wikidata
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Peptidyl-prolyl cis-trans isomerase FKBP1B is an enzyme that in humans is encoded by the FKBP1B gene.