FARSB

FARSB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3L4G
Identifiers
Aliases	FARSB, FARSLB, FRSB, PheHB, PheRS, HSPC173, phenylalanyl-tRNA synthetase beta subunit, phenylalanyl-tRNA synthetase subunit beta, NEDBLLA, RILDBC, RILDBC1
External IDs	OMIM: 609690; MGI: 1346035; HomoloGene: 4160; GeneCards: FARSB; OMA:FARSB - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	222,656,092 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	78,465,534 bp
RNA expression pattern
	Top expressed in
	myocardium of left ventricle; ; cardiac muscle tissue of right atrium; ; gingival epithelium; ; pancreatic epithelial cell; ; pancreatic ductal cell; ; skin of arm; ; middle temporal gyrus; ; Brodmann area 23; ; sperm; ; epithelium of nasopharynx;
	Top expressed in
	primitive streak; ; tail of embryo; ; genital tubercle; ; Paneth cell; ; condyle; ; fossa; ; secondary oocyte; ; barrel cortex; ; external carotid artery; ; zygote;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ligase activity; nucleotide binding; aminoacyl-tRNA ligase activity; magnesium ion binding; ATP binding; RNA binding; phenylalanine-tRNA ligase activity; protein binding;
Cellular component	membrane; cytosol; cytoplasm; phenylalanine-tRNA ligase complex;
Biological process	tRNA aminoacylation for protein translation; protein biosynthesis; protein heterotetramerization; phenylalanyl-tRNA aminoacylation;
	Sources:Amigo / QuickGO
Orthologs
	10056
	23874
	ENSG00000116120
	ENSMUSG00000026245
	Q9NSD9
	Q9WUA2
	NM_005687
	NM_001278075; NM_011811
	NP_005678
	NP_001265004; NP_035941
	Wikidata
View/Edit Human	View/Edit Mouse

Phenylalanyl-tRNA synthetase beta chain is an enzyme that in humans is encoded by the FARSB gene.

This gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily. This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the presence of ATP, this tetramer is responsible for attaching L-phenylalanine to the terminal adenosine of the appropriate tRNA. A pseudogene located on chromosome 10 has been identified.