FAM20C

FAM20C
Identifiers
Aliases	FAM20C, DMP-4, DMP4, GEF-CK, RNS, family with sequence similarity 20 member C, G-CK, golgi associated secretory pathway kinase, FAM20C golgi associated secretory pathway kinase
External IDs	OMIM: 611061; MGI: 2136853; HomoloGene: 56879; GeneCards: FAM20C; OMA:FAM20C - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	260,772 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	138,795,832 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; body of stomach; ; ascending aorta; ; human kidney; ; Descending thoracic aorta; ; popliteal artery; ; tibial arteries; ; muscle layer of sigmoid colon; ; right coronary artery; ; left coronary artery;
	Top expressed in
	molar; ; right kidney; ; medial geniculate nucleus; ; islet of Langerhans; ; medial dorsal nucleus; ; olfactory bulb; ; stria vascularis; ; proximal tubule; ; lateral geniculate nucleus; ; left lobe of liver;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; calcium ion binding; manganese ion binding; metal ion binding; kinase activity; protein binding; ATP binding; protein serine/threonine kinase activity; phosphotransferase activity, alcohol group as acceptor;
Cellular component	Golgi apparatus; extracellular region; extracellular exosome; extracellular space; cytoplasm; endoplasmic reticulum lumen;
Biological process	skeletal system development; phosphorylation; positive regulation of bone mineralization; osteoclast maturation; biomineral tissue development; regulation of fibroblast growth factor receptor signaling pathway; dentinogenesis; regulation of phosphorus metabolic process; protein phosphorylation; positive regulation of osteoblast differentiation; enamel mineralization; odontoblast differentiation; ATP metabolic process; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	56975
	80752
	ENSG00000177706; ENSG00000281429; ENSG00000282147; ENSG00000288499
	ENSMUSG00000025854
	Q8IXL6
	Q5MJS3
	NM_020223
	NM_030565; NM_001359593
	NP_064608
	NP_085042; NP_001346522
	Wikidata
View/Edit Human	View/Edit Mouse

Family with sequence similarity 20, member C also known as FAM20C or DMP4 is a protein which in humans is encoded by the FAM20C gene. Fam20C, a Golgi localized protein kinase, is a serine kinase that phosphorylates both casein and other highly acidic proteins and members of the small integrin-binding ligand, the N-linked glycoproteins (SIBLING) family at the target motif SerXGlu.