Fumarylacetoacetate hydrolase

FAH
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1HYO, 1QCN, 1QCO, 1QQJ, 2HZY
Identifiers
Aliases	FAH, Fumarylacetoacetase, fumarylacetoacetate hydrolase
External IDs	OMIM: 613871; MGI: 95482; HomoloGene: 110; GeneCards: FAH; OMA:FAH - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	80,186,946 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	84,255,930 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; right adrenal gland; ; right adrenal cortex; ; left adrenal cortex; ; adipose tissue; ; abdominal fat; ; C1 segment; ; subcutaneous adipose tissue; ; stromal cell of endometrium; ; human kidney;
	Top expressed in
	left lobe of liver; ; right kidney; ; human kidney; ; lactiferous gland; ; gallbladder; ; proximal tubule; ; brown adipose tissue; ; white adipose tissue; ; corneal stroma; ; subcutaneous adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	fumarylacetoacetase activity; protein binding; catalytic activity; hydrolase activity; metal ion binding;
Cellular component	cytosol; extracellular exosome;
Biological process	aromatic amino acid family metabolic process; metabolism; L-phenylalanine catabolic process; arginine catabolic process; tyrosine catabolic process; homogentisate catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	2184
	14085
	ENSG00000103876
	ENSMUSG00000030630
	P16930
	P35505
	NM_000137; NM_001374377; NM_001374380
	NM_010176
	NP_000128; NP_001361306; NP_001361309
	NP_034306
	Wikidata
View/Edit Human	View/Edit Mouse

Fumarylacetoacetase is an enzyme that in humans is encoded by the FAH gene located on chromosome 15. The enzyme is involved in the catabolism of the amino acid tyrosine in humans.