Oocyte activation

Oocyte (or ovum/egg) activation is a series of processes that occur in the oocyte during fertilization.

Sperm entry causes calcium release into the oocyte. In mammals, this is caused by the introduction of phospholipase C isoform zeta (PLCζ) from the sperm cytoplasm. Activation of the ovum includes the following events:

  • Cortical reaction to block against other sperm cells
  • Activation of egg metabolism
  • Reactivation of meiosis
  • DNA synthesis
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