Exosome component 1

EXOSC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2NN6
Identifiers
Aliases	EXOSC1, CGI-108, CSL4, Csl4p, SKI4, Ski4p, hCsl4p, p13, Exosome component 1, PCH1F
External IDs	OMIM: 606493; MGI: 1913833; HomoloGene: 9359; GeneCards: EXOSC1; OMA:EXOSC1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	97,446,017 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	41,921,862 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; stromal cell of endometrium; ; body of pancreas; ; monocyte; ; anterior pituitary; ; body of stomach; ; prefrontal cortex; ; gonad; ; mucosa of transverse colon; ; spleen;
	Top expressed in
	morula; ; tail of embryo; ; embryo; ; embryo; ; otic placode; ; zygote; ; epiblast; ; secondary oocyte; ; primary oocyte; ; genital tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	exoribonuclease activity; protein binding; RNA binding;
Cellular component	cytoplasm; cytosol; nuclear exosome (RNase complex); nucleolus; exosome (RNase complex); nucleoplasm; nucleus;
Biological process	regulation of mRNA stability; exonucleolytic catabolism of deadenylated mRNA; rRNA processing; RNA phosphodiester bond hydrolysis, exonucleolytic; RNA processing;
	Sources:Amigo / QuickGO
Orthologs
	51013
	66583
	ENSG00000171311
	ENSMUSG00000034321
	Q9Y3B2
	Q9DAA6
NM_016046; NM_001318362; NM_001318363; NM_001318364; NM_001318365;
	NM_001318366
	NM_001164561; NM_025644; NM_001320231; NM_001320232; NM_001320233
NP_001305291; NP_001305292; NP_001305293; NP_001305294; NP_001305295;
	NP_057130
	NP_001158033; NP_001307160; NP_001307161; NP_001307162; NP_079920
	Wikidata
View/Edit Human	View/Edit Mouse

3'-5' exoribonuclease CSL4 homolog is an enzyme that in humans is encoded by the EXOSC1 gene.

This gene encodes a core component of the exosome complex. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46.