ERLIN1

ERLIN1
Identifiers
Aliases	ERLIN1, C10orf69, Erlin-1, KE04, KEO4, SPFH1, SPG62, ER lipid raft associated 1
External IDs	OMIM: 611604; MGI: 2387613; HomoloGene: 4716; GeneCards: ERLIN1; OMA:ERLIN1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	100,186,033 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	44,058,224 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; palpebral conjunctiva; ; gingival epithelium; ; tibia; ; bronchial epithelial cell; ; trabecular bone; ; human penis; ; liver; ; jejunal mucosa; ; placenta;
	Top expressed in
	mucous cell of stomach; ; spermatocyte; ; epithelium of stomach; ; pyloric antrum; ; prostate; ; jejunum; ; cumulus cell; ; lumbar spinal ganglion; ; right kidney; ; lacrimal gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	cholesterol binding; protein binding; lipid binding; ubiquitin protein ligase binding;
Cellular component	integral component of membrane; membrane; endoplasmic reticulum; endoplasmic reticulum membrane; protein-containing complex;
Biological process	SREBP signaling pathway; steroid metabolic process; cholesterol metabolic process; negative regulation of cholesterol biosynthetic process; negative regulation of fatty acid biosynthetic process; lipid metabolism; ubiquitin-dependent ERAD pathway; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	10613
	226144
	ENSG00000107566
	ENSMUSG00000025198
	O75477
	Q91X78
NM_001100626; NM_001347856; NM_001347857; NM_001347858; NM_001347859;
	NM_001347860; NM_001347861; NM_006459
	NM_001164359; NM_001164360; NM_145502
NP_001094096; NP_001334785; NP_001334786; NP_001334787; NP_001334788;
	NP_001334789; NP_001334790; NP_006450
	NP_001157831; NP_001157832; NP_663477
	Wikidata
View/Edit Human	View/Edit Mouse

Erlin-1 (Endoplasmic Reticulum lipid raft-associated 1) is a protein encoded by the ERLIN1 gene in humans. ERLIN1 and its homolog ERLIN2 are ER-localized members of the stomatin/prohibition/flotillin/HflKC (SPFH) family of proteins. They form a complex that functions to scaffold lipids and proteins. ERLIN1 and ERLIN2 are predicted to assemble in a large ring-shaped hetero-oligomeric complex, likely formed by 24 subunits, similar to other members of the SPFH family.