ERG (gene)

ERG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1SXE, 4IRG, 4IRH, 4IRI
Identifiers
Aliases	ERG, erg-3, p55, ETS-related gene, v-ets avian erythroblastosis virus E26 oncogene homolog, ETS transcription factor, ETS transcription factor ERG
External IDs	OMIM: 165080; MGI: 95415; HomoloGene: 15848; GeneCards: ERG; OMA:ERG - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	38,661,780 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	95,387,452 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; Descending thoracic aorta; ; ascending aorta; ; visceral pleura; ; tibial arteries; ; sural nerve; ; subcutaneous adipose tissue; ; right lung; ; upper lobe of left lung; ; spleen;
	Top expressed in
	ascending aorta; ; external carotid artery; ; aortic valve; ; endothelial cell of lymphatic vessel; ; granulocyte; ; internal carotid artery; ; left lung lobe; ; zygote; ; phalanx of foot; ; yolk sac;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity; chromatin binding; signal transducer activity; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus; ribonucleoprotein complex;
Biological process	cell differentiation; regulation of transcription, DNA-templated; endocardial cushion development; endocardial cushion to mesenchymal transition involved in heart valve formation; transcription, DNA-templated; multicellular organism development; positive regulation of blood vessel remodeling; protein phosphorylation; cell population proliferation; cell migration; signal transduction; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	2078
	13876
	ENSG00000157554
	ENSMUSG00000040732
	P11308
	P81270
NM_001136154; NM_001136155; NM_001243428; NM_001243429; NM_001243432;
	NM_001243433; NM_001291391; NM_004449; NM_182918; NM_001331025
NM_133659; NM_001302152; NM_001302153; NM_001302154; NM_001302179;
	NM_001302183
NP_001129626; NP_001129627; NP_001230357; NP_001230358; NP_001230361;
	NP_001278320; NP_001317954; NP_004440; NP_891548
NP_001289081; NP_001289082; NP_001289083; NP_001289108; NP_001289112;
	NP_598420
	Wikidata
View/Edit Human	View/Edit Mouse

ERG (ETS-related gene) is an oncogene. ERG is a member of the ETS (erythroblast transformation-specific) family of transcription factors. The ERG gene encodes for a protein, also called ERG, that functions as a transcriptional regulator. Genes in the ETS family regulate embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis.