EPS15

EPS15
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1C07, 1EH2, 1F8H, 1FF1, 2IV9, 2JXC, 4RH5, 4RH9, 4RHG, 4S0G, 5JP2
Identifiers
Aliases	EPS15, AF-1P, AF1P, MLLT5, epidermal growth factor receptor pathway substrate 15
External IDs	OMIM: 600051; MGI: 104583; HomoloGene: 128359; GeneCards: EPS15; OMA:EPS15 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	51,519,266 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	109,245,014 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; sperm; ; internal globus pallidus; ; frontal pole; ; Brodmann area 23; ; middle temporal gyrus; ; pars compacta; ; lateral nuclear group of thalamus; ; corpus callosum; ; Pons;
	Top expressed in
	Region I of hippocampus proper; ; substantia nigra; ; cingulate gyrus; ; sciatic nerve; ; ventral tegmental area; ; deep cerebellar nuclei; ; lateral geniculate nucleus; ; cerebellar vermis; ; pontine nuclei; ; lobe of cerebellum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; SH3 domain binding; metal ion binding; polyubiquitin modification-dependent protein binding; protein binding; cadherin binding; identical protein binding; cargo receptor activity;
Cellular component	endosome; clathrin coat of coated pit; early endosome membrane; membrane; intracellular membrane-bounded organelle; plasma membrane; aggresome; ciliary membrane; clathrin-coated pit; AP-2 adaptor complex; clathrin-coated vesicle; basal plasma membrane; apical plasma membrane; early endosome; cytoplasm; cytosol; synapse; postsynapse; glutamatergic synapse;
Biological process	negative regulation of epidermal growth factor receptor signaling pathway; endocytosis; epidermal growth factor receptor signaling pathway; vesicle organization; Golgi to endosome transport; clathrin coat assembly; protein transport; viral entry into host cell; receptor-mediated endocytosis of virus by host cell; cell population proliferation; positive regulation of receptor recycling; regulation of cell population proliferation; endocytic recycling; membrane organization; viral process; transport; postsynaptic neurotransmitter receptor internalization;
	Sources:Amigo / QuickGO
Orthologs
	2060
	13858
	ENSG00000085832
	ENSMUSG00000028552
	P42566
	P42567
	NM_001159969; NM_001981
	NM_001159964; NM_007943
	NP_001153441; NP_001972
	NP_001153436; NP_031969
	Wikidata
View/Edit Human	View/Edit Mouse

Epidermal growth factor receptor substrate 15 is a protein that in humans is encoded by the EPS15 gene.