EMR3

ADGRE3
Identifiers
Aliases	ADGRE3, EMR3, adhesion G protein-coupled receptor E3
External IDs	OMIM: 606101; HomoloGene: 50009; GeneCards: ADGRE3; OMA:ADGRE3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	14,690,027 bp
RNA expression pattern
	Top expressed in
	blood; ; monocyte; ; granulocyte; ; gonad; ; appendix; ; bone marrow; ; bone marrow cells; ; spleen; ; right lung; ; gallbladder;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; G protein-coupled receptor activity; transmembrane signaling receptor activity; signal transducer activity;
Cellular component	integral component of membrane; extracellular region; membrane; plasma membrane; secretory granule membrane; ficolin-1-rich granule membrane; integral component of plasma membrane;
Biological process	G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; signal transduction; neutrophil degranulation; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	84658
	n/a
	ENSG00000131355
	n/a
	Q9BY15
	n/a
	NM_001289158; NM_001289159; NM_032571; NM_152939
	n/a
	NP_001276087; NP_001276088; NP_115960
	n/a
	Wikidata
View/Edit Human

EGF-like module-containing mucin-like hormone receptor-like 3 is a protein encoded by the ADGRE3 gene. EMR3 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

EMR3 expression is restricted to monocytes/macrophages, myeloid dendritic cells, and mature granulocytes in human. Transcription of the EMR3 gene results in two alternative spliced forms: a surface protein with extracellular, 7TM, and intracellular domains as well as a truncated soluble form of only the extracellular domain. Mice, next to Emr2, lack the Emr3 gene.