ELOA

ELOA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4HFX
Identifiers
Aliases	ELOA, EloA, SIII, SIII p110, TCEB3A, TCEB3, transcription elongation factor B subunit 3, elongin A
External IDs	OMIM: 600786; MGI: 1351315; HomoloGene: 37746; GeneCards: ELOA; OMA:ELOA - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	23,762,059 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	135,749,074 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; lower lobe of lung; ; cardia; ; glutes; ; Skeletal muscle tissue of biceps brachii; ; myocardium of left ventricle; ; skin of arm; ; Skeletal muscle tissue of rectus abdominis; ; gingival epithelium; ; thoracic diaphragm;
	Top expressed in
	molar; ; granulocyte; ; plantaris muscle; ; extensor digitorum longus muscle; ; triceps brachii muscle; ; ankle; ; medial head of gastrocnemius muscle; ; temporal muscle; ; quadriceps femoris muscle; ; muscle of thigh;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	nucleus; nucleoplasm; extracellular space; elongin complex;
Biological process	transcription elongation from RNA polymerase II promoter; regulation of transcription, DNA-templated; transcription by RNA polymerase II; transcription, DNA-templated; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	6924
	27224
	ENSG00000011007
	ENSMUSG00000028668
	Q14241
	Q8CB77
	NM_003198
	NM_013736
	NP_003189
	NP_038764
	Wikidata
View/Edit Human	View/Edit Mouse

Elongin A is a protein that in humans is encoded by the ELOA gene.

Elongin A is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis and is capable of forming a stable complex with elongins B and C. The von Hippel–Lindau tumor suppressor protein binds to elongins B and C and thereby inhibits transcription elongation.