ELMO (protein)
| ELMO/CED-12 family | |||||||||
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| Identifiers | |||||||||
| Symbol | ELMO_CED12 | ||||||||
| Pfam | PF04727 | ||||||||
| InterPro | IPR006816 | ||||||||
| PROSITE | PDOC51335 | ||||||||
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ELMO (Engulfment and Cell Motility) is a family of related proteins (~82 kDa) involved in intracellular signalling networks. These proteins have no intrinsic catalytic activity and instead function as adaptors which can regulate the activity of other proteins through their ability to mediate protein-protein interactions.
This family contains members in all animals. In humans there are three paralogous isoforms:
The ELMO domain was first characterized in the CED-12 proteins of Caenorhabditis elegans and Drosophila melanogaster, which is a homolog to the ELMO protein found in mammals. This protein is involved in Rac-GTPase activation, apoptotic cell phagocytosis, cell migration, and cytoskeletal rearrangements.