EIF4H

EIF4H
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DNG
Identifiers
Aliases	EIF4H, WBSCR1, WSCR1, eIF-4H, eukaryotic translation initiation factor 4H
External IDs	OMIM: 603431; MGI: 1341822; HomoloGene: 32536; GeneCards: EIF4H; OMA:EIF4H - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	74,197,122 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	134,668,344 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; skin of leg; ; C1 segment; ; body of pancreas; ; muscle layer of sigmoid colon; ; gastrocnemius muscle; ; gastric mucosa; ; prefrontal cortex; ; skin of abdomen; ; cerebellar hemisphere;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; primitive streak; ; medullary collecting duct; ; Paneth cell; ; left lung lobe; ; vestibular membrane of cochlear duct; ; Gonadal ridge; ; motor neuron; ; vestibular sensory epithelium;
	More reference expression data
	n/a
Gene ontology
Molecular function	translation factor activity, RNA binding; protein binding; nucleic acid binding; ribosomal small subunit binding; RNA strand-exchange activity; helicase activity; RNA strand annealing activity; RNA binding; translation initiation factor activity; cadherin binding;
Cellular component	cytoplasm; perinuclear region of cytoplasm; cytosol; eukaryotic translation initiation factor 4F complex; membrane; polysome;
Biological process	translational initiation; viral process; developmental growth; sexual reproduction; regulation of translational initiation; protein biosynthesis; eukaryotic translation initiation factor 4F complex assembly; formation of translation preinitiation complex; cytoplasmic translation;
	Sources:Amigo / QuickGO
Orthologs
	7458
	22384
	ENSG00000106682
	ENSMUSG00000040731
	Q15056
	Q9WUK2
	NM_022170; NM_031992
	NM_033561; NM_001312867
	NP_071496; NP_114381
	NP_001299796; NP_291039
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic translation initiation factor 4H is a protein that in humans is encoded by the EIF4H gene.

This gene encodes one of the translation initiation factors, which function to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants.

EIF4H appears analogous to drr-2 in C. elegans which regulates the mTOR pathway and affects longevity.