EIF3A

EIF3A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3J8B, 3J8C
Identifiers
Aliases	EIF3A, EIF3, EIF3S10, P167, TIF32, eIF3-p170, eIF3-theta, p180, p185, eukaryotic translation initiation factor 3 subunit A
External IDs	OMIM: 602039; MGI: 95301; HomoloGene: 2779; GeneCards: EIF3A; OMA:EIF3A - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	119,080,823 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	60,779,096 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; tibia; ; buccal mucosa cell; ; amniotic fluid; ; epithelium of nasopharynx; ; gingival epithelium; ; skin of thigh; ; mucosa of paranasal sinus; ; skin of hip; ; glutes;
	Top expressed in
	lacrimal gland; ; tail of embryo; ; maxillary prominence; ; mandibular prominence; ; otic placode; ; human fetus; ; saccule; ; primitive streak; ; hair follicle; ; seminal vesicula;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; structural molecule activity; translation initiation factor activity; receptor tyrosine kinase binding; RNA binding; mRNA binding;
Cellular component	eukaryotic translation initiation factor 3 complex; nucleolus; nucleus; membrane; microtubule; cytoplasm; cytosol; multi-eIF complex; eukaryotic translation initiation factor 3 complex, eIF3e; eukaryotic translation initiation factor 3 complex, eIF3m; postsynaptic density; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex;
Biological process	translational initiation; formation of cytoplasmic translation initiation complex; viral translational termination-reinitiation; protein biosynthesis; IRES-dependent viral translational initiation; negative regulation of ERK1 and ERK2 cascade; translation reinitiation; cytoplasmic translational initiation;
	Sources:Amigo / QuickGO
Orthologs
	8661
	13669
	ENSG00000107581
	ENSMUSG00000024991
	Q14152
	P23116
	NM_003750
	NM_010123
	NP_003741
	NP_034253
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic translation initiation factor 3 subunit A (eIF3a) is a protein that in humans is encoded by the EIF3A gene. It is one of the subunits of Eukaryotic initiation factor 3 (eIF3) a multiprotein complex playing major roles in translation initiation in eukaryotes.