EGR1

EGR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4R2A, 4R2C, 4R2D, 4X9J
Identifiers
Aliases	EGR1, AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225, early growth response 1
External IDs	OMIM: 128990; MGI: 95295; HomoloGene: 56394; GeneCards: EGR1; OMA:EGR1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	138,469,303 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	34,998,037 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; left uterine tube; ; gallbladder; ; saphenous vein; ; vena cava; ; skin of thigh; ; nipple; ; periodontal fiber; ; seminal vesicula; ; renal medulla;
	Top expressed in
	granulocyte; ; prefrontal cortex; ; dorsal striatum; ; cingulate gyrus; ; primary motor cortex; ; visual cortex; ; cumulus cell; ; nucleus accumbens; ; primary visual cortex; ; superior frontal gyrus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription cis-regulatory region binding; metal ion binding; transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding; protein binding; histone acetyltransferase binding; nucleic acid binding; hemi-methylated DNA-binding; double-stranded methylated DNA binding; zinc ion binding; promoter-specific chromatin binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleoplasm; nucleus; cytoplasm;
Biological process	regulation of apoptotic process; cellular response to organic substance; regulation of transcription, DNA-templated; glomerular mesangial cell proliferation; negative regulation of transcription by RNA polymerase II; response to glucose; transcription by RNA polymerase II; BMP signaling pathway; transcription, DNA-templated; positive regulation of transcription, DNA-templated; response to insulin; interleukin-1-mediated signaling pathway; cellular response to mycophenolic acid; T cell differentiation; type I interferon signaling pathway; positive regulation of glomerular metanephric mesangial cell proliferation; cellular response to gamma radiation; regulation of transcription from RNA polymerase II promoter in response to hypoxia; skeletal muscle cell differentiation; cellular response to heparin; regulation of protein sumoylation; negative regulation of canonical Wnt signaling pathway; positive regulation of transcription by RNA polymerase II; cellular response to interleukin-8; response to hypoxia; response to ischemia; estrous cycle; positive regulation of hormone biosynthetic process; regulation of progesterone biosynthetic process; regulation of transcription by RNA polymerase II; positive regulation of gene expression; circadian regulation of gene expression; locomotor rhythm; rhythmic process; circadian temperature homeostasis; positive regulation of neuron death; positive regulation of tau-protein kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	1958
	13653
	ENSG00000120738
	ENSMUSG00000038418
	P18146
	P08046
	NM_001964
	NM_007913
	NP_001955
	NP_031939
	Wikidata
View/Edit Human	View/Edit Mouse

EGR-1 (Early growth response protein 1) or NGFI-A (nerve growth factor-induced protein A) is a protein that in humans is encoded by the EGR1 gene.

EGR-1 is a mammalian transcription factor. It was also named Krox-24, TIS8, and ZENK. It was originally discovered in mice.