EDC3

EDC3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2VC8, 2WAX, 2WAY, 3D3J, 3D3K
Identifiers
Aliases	EDC3, LSM16, YJDC, YJEFN2, MRT50, enhancer of mRNA decapping 3, hYjeF_N2-15q23
External IDs	OMIM: 609842; MGI: 2142951; HomoloGene: 11827; GeneCards: EDC3; OMA:EDC3 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	74,696,292 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	57,659,782 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; stromal cell of endometrium; ; ganglionic eminence; ; ventricular zone; ; testicle; ; islet of Langerhans; ; gonad; ; granulocyte; ; right lobe of thyroid gland;
	Top expressed in
	primitive streak; ; hand; ; otolith organ; ; yolk sac; ; Rostral migratory stream; ; utricle; ; otic vesicle; ; external carotid artery; ; trigeminal ganglion; ; internal carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; phosphodiesterase decapping endonuclease activity; identical protein binding; RNA binding; mRNA binding;
Cellular component	cytoplasm; cytosol; membrane; P-body; cytoplasmic ribonucleoprotein granule;
Biological process	P-body assembly; exonucleolytic catabolism of deadenylated mRNA; RNA phosphodiester bond hydrolysis, endonucleolytic; deadenylation-independent decapping of nuclear-transcribed mRNA;
	Sources:Amigo / QuickGO
Orthologs
	80153
	353190
	ENSG00000179151
	ENSMUSG00000038957
	Q96F86
	Q8K2D3
	NM_001142443; NM_001142444; NM_025083; NM_001351378; NM_001351379
	NM_153799
	NP_001135915; NP_001135916; NP_079359; NP_001338307; NP_001338308
	NP_722494
	Wikidata
View/Edit Human	View/Edit Mouse

Enhancer of mRNA-decapping protein 3 is a protein that in humans is encoded by the EDC3 gene.

EDC3 is associated with an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).[supplied by OMIM]