Ditolylguanidine

Ditolylguanidine
Clinical data
ATC code	none;
Identifiers
	IUPAC name 1,2-bis(2-methylphenyl)guanidine;
CAS Number	97-39-2 ;
PubChem CID	7333;
IUPHAR/BPS	6684;
ChemSpider	7056 ;
UNII	LL2P01I17O;
ChEMBL	ChEMBL282433 ;
CompTox Dashboard (EPA)	DTXSID2026606 ;
ECHA InfoCard	100.002.344
Chemical and physical data
Formula	C15H17N3
Molar mass	239.322 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES N(=C(/Nc1ccccc1C)N)\c2ccccc2C;
	InChI InChI=1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18) ; Key:OPNUROKCUBTKLF-UHFFFAOYSA-N ;
	(verify)

Ditolylguanidine is a sigma receptor agonist. It is somewhat selective for sigma receptors, but non-selective between the two sigma receptor subtypes, binding to both σ1 and σ2 with equal affinity. It has neuroprotective and antidepressant effects, and potentiates the effects of NMDA antagonists.

Clinical data


ATC code	none
Identifiers
IUPAC name 1,2-bis(2-methylphenyl)guanidine
CAS Number	97-39-2^Y
PubChem CID	7333
IUPHAR/BPS	6684
ChemSpider	7056^Y
UNII	LL2P01I17O
ChEMBL	ChEMBL282433^Y
CompTox Dashboard (EPA)	DTXSID2026606
ECHA InfoCard	100.002.344
Chemical and physical data
Formula	C₁₅H₁₇N₃
Molar mass	239.322 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES N(=C(/Nc1ccccc1C)N)\c2ccccc2C
InChI InChI=1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18)^Y Key:OPNUROKCUBTKLF-UHFFFAOYSA-N^Y
(verify)