Eudysmic ratio

The eudysmic ratio (also spelled eudismic ratio) represents the difference in pharmacologic activity between the two enantiomers of a drug. In most cases where a chiral compound is biologically active, one enantiomer is more active than the other. The eudysmic ratio is the ratio of activity between the two. A eudysmic ratio significantly differing from 1 means that they are statistically different in activity. Eudysmic ratio (ER) reflects the degree of enantioselectivity of the biological systems. For example, (S)-propranolol has ER = 130, meaning that (S)-propranolol is 130 times more active than its (R)-enantiomer.

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