Diguanylate cyclase
| diguanylate cyclase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Crystal structure of diguanylate cyclase PleD in complex with c-di-GMP from Caulobacter crescentus; rendering based on PDB: 2WB4 | |||||||||
| Identifiers | |||||||||
| EC no. | 2.7.7.65 | ||||||||
| CAS no. | 146316-82-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, diguanylate cyclase, also known as diguanylate kinase (EC 2.7.7.65), is an enzyme that catalyzes the chemical reaction:
2 Guanosine triphosphate ↔ 2 diphosphate + cyclic di-3',5'-guanylate
The substrates of diguanylate cyclases (DGCs) are two molecules of guanosine triphosphate (GTP) and the products are two molecules of diphosphate and one molecule of cyclic di-3’,5’-guanylate (cyclic di-GMP).
Degradation of cyclic di-GMP to guanosine monophosphate (GMP) is catalyzed by a phosphodiesterase (PDE).