Difenoxin

Difenoxin
Clinical data
Other names	Difenoxin, Motofen
AHFS/Drugs.com	International Drug Names
ATC code	A07DA04 (WHO) ;
Legal status
Legal status	AU: S8 (Controlled drug); BR: Class A1 (Narcotic drugs); CA: Schedule I; DE: Prescription only (Anlage II for higher doses) if combined with atropine sulphate; US: Schedule I (by itself); Schedule IV-V (with atropine);
Identifiers
	IUPAC name 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylic acid;
CAS Number	28782-42-5 ; HCl: 35607-36-4 ;
PubChem CID	34328;
IUPHAR/BPS	7592;
DrugBank	DB01501 ;
ChemSpider	31620 ;
UNII	3ZZ5BJ9F2Q; HCl: VQZ63K01IW ;
KEGG	D03809 ;
ChEBI	CHEBI:4534 ;
ChEMBL	ChEMBL1201321 ;
CompTox Dashboard (EPA)	DTXSID0022931 ;
Chemical and physical data
Formula	C28H28N2O2
Molar mass	424.544 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C(CCN1CCC(CC1)(C(O)=O)C2=CC=CC=C2)(C3=CC=CC=C3)(C4=CC=CC=C4)C#N;
	InChI InChI=1S/C28H28N2O2/c29-22-28(24-12-6-2-7-13-24,25-14-8-3-9-15-25)18-21-30-19-16-27(17-20-30,26(31)32)23-10-4-1-5-11-23/h1-15H,16-21H2,(H,31,32) ; Key:UFIVBRCCIRTJTN-UHFFFAOYSA-N ;
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Difenoxin (Motofen, R-15403) is an opioid drug used, often in combination with atropine, to treat diarrhea. It is the principal metabolite of diphenoxylate.^: 558

It was first approved in the US in 1978 and in 1980 in the former West Germany.^: 485

Difenoxin crosses the blood brain barrier and induces some euphoria; it is often sold with or administered with atropine to reduce the potential for abuse and overdose.