Dalfopristin

Dalfopristin
Clinical data

AHFS/Drugs.com	International Drug Names
MedlinePlus	a603007
ATC code	none
Legal status
Legal status	US: ℞-only
Pharmacokinetic data
Elimination half-life	1 hour
Identifiers
IUPAC name (3R,4R,5E,10E,12E,14S,26R,26aS)-26-[[2-(diethylamino)ethyl]sulfonyl]-8,9,14,15,24,25,26,26a- octahydro-14-hydroxy-3-isopropyl-4,12-dimethyl-3H-21,18-nitrilo-1H,22H-pyrrolo[2,1-c] [1,8,4,19]-dioxadiazacyclotetracosine-1,7,16,22(4H,17H)-tetrone
CAS Number	112362-50-2^Y
PubChem CID	6435782
DrugBank	DB01764^N
ChemSpider	16736919^N
UNII	R9M4FJE48E
KEGG	D00853^N
ChEBI	CHEBI:4309
ChEMBL	ChEMBL1200937^N
CompTox Dashboard (EPA)	DTXSID10869549
Chemical and physical data
Formula	C₃₄H₅₀N₄O₉S
Molar mass	690.85 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCN(CC)CCS(=O)(=O)[C@@H]1CCN2[C@H]1C(=O)O[C@@H]([C@@H](/C=C/C(=O)NC/C=C/C(=C/[C@H](CC(=O)CC3=NC(=CO3)C2=O)O)/C)C)C(C)C
InChI InChI=1S/C34H50N4O9S/c1-7-37(8-2)16-17-48(44,45)28-13-15-38-31(28)34(43)47-32(22(3)4)24(6)11-12-29(41)35-14-9-10-23(5)18-25(39)19-26(40)20-30-36-27(21-46-30)33(38)42/h9-12,18,21-22,24-25,28,31-32,39H,7-8,13-17,19-20H2,1-6H3,(H,35,41)/b10-9+,12-11+,23-18+/t24-,25-,28-,31-,32-/m1/s1^N Key:SUYRLXYYZQTJHF-VMBLUXKRSA-N^N
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Dalfopristin is a semi-synthetic streptogramin antibiotic analogue of ostreogyrcin A (virginiamycin M, pristinamycin IIA, streptogramin A). The combination quinupristin/dalfopristin (marketed under the trade name Synercid) was brought to the market by Rhone-Poulenc Rorer Pharmaceuticals in 1999. Synercid (weight-to-weight ratio of 30% quinupristin to 70% dalfopristin) is used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium.