Desmoglein-2

DSG2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YQG, 5ERD, 5J5J
Identifiers
Aliases	DSG2, ARVC10, ARVD10, CDHF5, CMD1BB, HDGC, desmoglein 2
External IDs	OMIM: 125671; MGI: 1196466; HomoloGene: 1464; GeneCards: DSG2; OMA:DSG2 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	31,549,008 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	20,737,578 bp
RNA expression pattern
	Top expressed in
	mucosa of sigmoid colon; ; jejunal mucosa; ; palpebral conjunctiva; ; parotid gland; ; hair follicle; ; rectum; ; lactiferous duct; ; Epithelium of choroid plexus; ; duodenum; ; germinal epithelium;
	Top expressed in
	left colon; ; transitional epithelium of urinary bladder; ; parotid gland; ; epithelium of stomach; ; Paneth cell; ; crypt of lieberkuhn of small intestine; ; lacrimal gland; ; submandibular gland; ; pyloric antrum; ; mucous cell of stomach;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; metal ion binding; cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication; cell adhesion molecule binding;
Cellular component	integral component of membrane; lateral plasma membrane; membrane; intercalated disc; cell-cell junction; plasma membrane; desmosome; cell surface; cell junction; apical plasma membrane; extracellular exosome; cornified envelope; intracellular membrane-bounded organelle;
Biological process	desmosome organization; maternal process involved in female pregnancy; response to progesterone; bundle of His cell-Purkinje myocyte adhesion involved in cell communication; cell adhesion; Purkinje myocyte development; regulation of heart rate by cardiac conduction; regulation of ventricular cardiac muscle cell action potential; homophilic cell adhesion via plasma membrane adhesion molecules; keratinization; cornification; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	1829
	13511
	ENSG00000046604
	ENSMUSG00000044393
	Q14126
	O55111
	NM_001943
	NM_007883
	NP_001934
	NP_031909
	Wikidata
View/Edit Human	View/Edit Mouse

Desmoglein-2 is a protein that in humans is encoded by the DSG2 gene. Desmoglein-2 is highly expressed in epithelial cells and cardiomyocytes. Desmoglein-2 is localized to desmosome structures at regions of cell-cell contact and functions to structurally adhere adjacent cells together. In cardiac muscle, these regions are specialized regions known as intercalated discs. Mutations in desmoglein-2 have been associated with arrhythmogenic right ventricular cardiomyopathy and familial dilated cardiomyopathy.