| DPP8 |
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| Identifiers |
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| Aliases | DPP8, DP8, DPRP1, MSTP141, MST097, MSTP097, MSTP135, DPRP-1, dipeptidyl peptidase 8 |
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| External IDs | OMIM: 606819; MGI: 1921638; HomoloGene: 57098; GeneCards: DPP8; OMA:DPP8 - orthologs |
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| Gene location (Mouse) |
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| | Chr. | Chromosome 9 (mouse) |
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| | Band | 9|9 C | Start | 64,939,696 bp |
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| End | 64,989,933 bp |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - buccal mucosa cell
- secondary oocyte
- nipple
- middle temporal gyrus
- Pons
- postcentral gyrus
- Skeletal muscle tissue of rectus abdominis
- lateral nuclear group of thalamus
- Brodmann area 23
- biceps brachii
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| | Top expressed in | - spermatocyte
- muscle of thigh
- superior frontal gyrus
- aortic valve
- cerebellar cortex
- dentate gyrus of hippocampal formation granule cell
- ascending aorta
- temporal muscle
- inferior colliculi
- perirhinal cortex
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| | More reference expression data |
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| BioGPS | |
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| Wikidata |
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Dipeptidyl peptidase 8 is an enzyme that in humans is encoded by the DPP8 gene.
This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase-4 in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described. A relatively specific inhibitor of DPP8 and DPP9, Val-boroPro -, leads to increased activation of the inflammasome though both NLRBP1 and CARD8 and can trigger pyroptosis.
