DNAJA2

DNAJA2
Identifiers
Aliases	DNAJA2, CPR3, DJ3, DJA2, DNAJ, DNJ3, HIRIP4, PRO3015, RDJ2, DnaJ heat shock protein family (Hsp40) member A2
External IDs	OMIM: 611322; MGI: 1931882; HomoloGene: 21193; GeneCards: DNAJA2; OMA:DNAJA2 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	46,973,674 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	86,281,973 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; gastrocnemius muscle; ; endothelial cell; ; sperm; ; muscle of thigh; ; Skeletal muscle tissue of rectus abdominis; ; germinal epithelium; ; mucosa of paranasal sinus; ; right auricle of heart; ; prefrontal cortex;
	Top expressed in
	neural layer of retina; ; triceps brachii muscle; ; sternocleidomastoid muscle; ; medial ganglionic eminence; ; temporal muscle; ; digastric muscle; ; urothelium; ; abdominal wall; ; transitional epithelium of urinary bladder; ; atrioventricular valve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	unfolded protein binding; chaperone binding; protein binding; ATP binding; heat shock protein binding; metal ion binding; ATPase activator activity;
Cellular component	extracellular exosome; membrane; cytosol;
Biological process	response to heat; protein folding; protein refolding; positive regulation of cell population proliferation; positive regulation of ATP-dependent activity;
	Sources:Amigo / QuickGO
Orthologs
	10294
	56445
	ENSG00000069345
	ENSMUSG00000031701
	O60884
	Q9QYJ0
	NM_005880
	NM_019794
	NP_005871
	NP_062768
	Wikidata
View/Edit Human	View/Edit Mouse

DnaJ homolog subfamily A member 2 is a protein that in humans is encoded by the DNAJA2 gene.

The protein encoded by this gene shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of this protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding interacting proteins, HIRIPs, have been identified. HIRIP4 was isolated by virtue of its interaction with this protein; however, its exact function is not known. The sequence of HIRIP4 protein is highly homologous to the human DNJ3/CPR3, mouse Dj3 and rat Dj2 gene products.