DLG3

DLG3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UM7, 2FE5, 2I1N
Identifiers
Aliases	DLG3, MRX, MRX90, NEDLG, PPP1R82, SAP102, XLMR, discs large homolog 3, discs large MAGUK scaffold protein 3, XLID90
External IDs	OMIM: 300189; MGI: 1888986; HomoloGene: 41157; GeneCards: DLG3; OMA:DLG3 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	70,505,490 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	99,862,016 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; buccal mucosa cell; ; ganglionic eminence; ; rectum; ; olfactory zone of nasal mucosa; ; islet of Langerhans; ; middle temporal gyrus; ; pancreatic ductal cell; ; mucosa of transverse colon; ; prefrontal cortex;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; retinal pigment epithelium; ; superior frontal gyrus; ; hippocampus proper; ; cingulate gyrus; ; piriform cortex; ; olfactory tubercle; ; primary visual cortex; ; Region I of hippocampus proper; ; Amygdala;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	phosphatase binding; PDZ domain binding; protein domain specific binding; guanylate kinase activity; kinase binding; protein C-terminus binding; protein binding; ionotropic glutamate receptor binding; protein phosphatase binding; ubiquitin protein ligase binding; ligand-gated ion channel activity; structural constituent of postsynaptic density;
Cellular component	cytoplasm; postsynaptic membrane; postsynaptic density; cell-cell junction; bicellular tight junction; growth cone; plasma membrane; synapse; dendritic shaft; soma; basolateral plasma membrane; AMPA glutamate receptor complex; ionotropic glutamate receptor complex; extracellular space; cytosol; cell junction; neuromuscular junction; neuron projection; postsynaptic density membrane; glutamatergic synapse; postsynaptic density, intracellular component;
Biological process	receptor localization to synapse; negative regulation of phosphatase activity; establishment of planar polarity; receptor clustering; nervous system development; establishment or maintenance of epithelial cell apical/basal polarity; negative regulation of cell population proliferation; ion transmembrane transport; GMP metabolic process; GDP metabolic process; chemical synaptic transmission; MAPK cascade; positive regulation of protein tyrosine kinase activity; cell-cell adhesion; regulation of postsynaptic membrane neurotransmitter receptor levels; maintenance of postsynaptic density structure; regulation of NMDA receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	1741
	53310
	ENSG00000082458
	ENSMUSG00000000881
	Q92796
	P70175
	NM_001166278; NM_020730; NM_021120
	NM_001177778; NM_001177779; NM_001177780; NM_001290402; NM_016747
	NP_001159750; NP_065781; NP_066943
	NP_001171249; NP_001171250; NP_001171251; NP_001277331; NP_058027
	Wikidata
View/Edit Human	View/Edit Mouse

Disks large homolog 3 (DLG3) also known as neuroendocrine-DLG or synapse-associated protein 102 (SAP-102) is a protein that in humans is encoded by the DLG3 gene. DLG3 is a member of the membrane-associated guanylate kinase (MAGUK) superfamily of proteins.