DKK1

DKK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3S2K, 3S8V, 3SOQ, 5FWW
Identifiers
Aliases	DKK1, DKK-1, SK, dickkopf WNT signaling pathway inhibitor 1
External IDs	OMIM: 605189; MGI: 1329040; HomoloGene: 7689; GeneCards: DKK1; OMA:DKK1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	52,318,042 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	30,527,065 bp
RNA expression pattern
	Top expressed in
	decidua; ; stromal cell of endometrium; ; mucosa of urinary bladder; ; epithelium of esophagus; ; tibia; ; canal of the cervix; ; gonad; ; sperm; ; skin of leg; ; vagina;
	Top expressed in
	membranous bone; ; mandible; ; desmocranium; ; calvaria; ; eyelid; ; Jacobson's organ; ; molar; ; dermis; ; fossa; ; maxilla;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	co-receptor binding; signal transducer activity; low-density lipoprotein particle receptor binding; protein binding; growth factor activity; receptor antagonist activity;
Cellular component	early endosome membrane; plasma membrane; extracellular region; extracellular space;
Biological process	hair follicle development; Wnt signaling pathway involved in somitogenesis; endoderm development; head morphogenesis; response to retinoic acid; negative regulation of Wnt-Frizzled-LRP5/6 complex assembly; positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway; negative regulation of mesodermal cell fate specification; negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment; negative regulation of Wnt signaling pathway; mesoderm formation; negative regulation of transcription by RNA polymerase II; Wnt signaling pathway; negative regulation of protein binding; negative regulation of pathway-restricted SMAD protein phosphorylation; negative regulation of BMP signaling pathway; multicellular organism development; motor learning; regulation of Wnt signaling pathway; embryonic limb morphogenesis; negative regulation of skeletal muscle tissue development; negative regulation of cardiac muscle cell differentiation; negative regulation of peptidyl-serine phosphorylation; regulation of receptor internalization; forebrain development; cell morphogenesis involved in differentiation; endoderm formation; regulation of synaptic transmission, glutamatergic; regulation of endodermal cell fate specification; regulation of synapse organization; negative regulation of canonical Wnt signaling pathway; face morphogenesis; synapse pruning; extracellular negative regulation of signal transduction; regulation of dopaminergic neuron differentiation; positive regulation of midbrain dopaminergic neuron differentiation; negative regulation of ossification; negative regulation of apoptotic process; limb development; learning or memory; regulation of signaling receptor activity; positive regulation of gene expression; positive regulation of cell death; positive regulation of JUN kinase activity; positive regulation of Wnt signaling pathway, calcium modulating pathway; positive regulation of neuron death; positive regulation of tau-protein kinase activity; positive regulation of Wnt signaling pathway, planar cell polarity pathway; negative regulation of neuron projection development; negative regulation of presynapse assembly; negative regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	22943
	13380
	ENSG00000107984
	ENSMUSG00000024868
	O94907
	O54908
	NM_012242
	NM_010051
	NP_036374
	NP_034181
	Wikidata
View/Edit Human	View/Edit Mouse

Dickkopf-related protein 1 is a protein that in humans is encoded by the DKK1 gene.