Diablo homolog

DIABLO
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FEW, 1G3F, 1G73, 1OXQ, 1TW6, 1XB0, 1XB1, 3D9U, 3UIH, 3UIJ, 4TX5
Identifiers
Aliases	DIABLO, DFNA64, SMAC, Diablo, Diablo homolog, diablo IAP-binding mitochondrial protein
External IDs	OMIM: 605219; MGI: 1913843; HomoloGene: 10532; GeneCards: DIABLO; OMA:DIABLO - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	122,227,456 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	123,662,239 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; islet of Langerhans; ; anterior pituitary; ; ganglionic eminence; ; gonad; ; Hypothalamus; ; C1 segment; ; substantia nigra; ; ventricular zone;
	Top expressed in
	spermatocyte; ; spermatid; ; muscle of thigh; ; embryo; ; right kidney; ; ventricular zone; ; morula; ; embryo; ; lip; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytosol; mitochondrial intermembrane space; mitochondrion; cytoplasmic side of plasma membrane; CD40 receptor complex;
Biological process	intrinsic apoptotic signaling pathway; activation of cysteine-type endopeptidase activity involved in apoptotic process; extrinsic apoptotic signaling pathway via death domain receptors; apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; positive regulation of apoptotic process; intrinsic apoptotic signaling pathway in response to oxidative stress; neuron apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	56616
	66593
	ENSG00000184047
	ENSMUSG00000029433
	Q9NR28
	Q9JIQ3
NM_138930; NM_001278302; NM_001278303; NM_001278304; NM_001278342;
	NM_019887; NM_138929; NM_001371333
	NM_023232
NP_001265231; NP_001265232; NP_001265233; NP_001265271; NP_063940;
	NP_620308; NP_001358262; NP_001265231.1
	NP_075721
	Wikidata
View/Edit Human	View/Edit Mouse

Diablo homolog (DIABLO) is a mitochondrial protein that in humans is encoded by the DIABLO (direct IAP binding protein with low pI) gene on chromosome 12. DIABLO is also referred to as second mitochondria-derived activator of caspases or SMAC. This protein binds inhibitor of apoptosis proteins (IAPs), thus freeing caspases to activate apoptosis. Due to its proapoptotic function, SMAC is implicated in a broad spectrum of tumors, and small molecule SMAC mimetics have been developed to enhance current cancer treatments.