DEPDC5

DEPDC5
Identifiers
Aliases	DEPDC5, DEP.5, FFEVF, DEP domain containing 5, FFEVF1, DEP domain containing 5, GATOR1 subcomplex subunit
External IDs	OMIM: 614191; MGI: 2141101; HomoloGene: 34718; GeneCards: DEPDC5; OMA:DEPDC5 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	31,908,033 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	33,151,580 bp
RNA expression pattern
	Top expressed in
	paraflocculus of cerebellum; ; frontal pole; ; middle frontal gyrus; ; epithelium of colon; ; Brodmann area 10; ; ventricular zone; ; sural nerve; ; testicle; ; mucosa of transverse colon; ; Achilles tendon;
	Top expressed in
	spermatocyte; ; lumbar subsegment of spinal cord; ; tail of embryo; ; spermatid; ; lumbar spinal ganglion; ; yolk sac; ; ventricular zone; ; dentate gyrus of hippocampal formation granule cell; ; neural layer of retina; ; genital tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein-containing complex binding; GTPase activator activity;
Cellular component	cytoplasm; perinuclear region of cytoplasm; GATOR1 complex; cytosol; lysosome; lysosomal membrane; membrane; Cul3-RING ubiquitin ligase complex; intracellular anatomical structure;
Biological process	negative regulation of TOR signaling; cellular response to amino acid starvation; intracellular signal transduction; positive regulation of GTPase activity; negative regulation of TORC1 signaling; regulation of autophagy;
	Sources:Amigo / QuickGO
Orthologs
	9681
	277854
	ENSG00000100150
	ENSMUSG00000037426
	O75140
	P61460
NM_001007188; NM_001136029; NM_001242896; NM_001242897; NM_014662;
	NM_001363852; NM_001363854; NM_001364318; NM_001364319; NM_001364320; NM_001369901; NM_001369902; NM_001369903
	NM_001025426; NM_001170567; NM_177786; NM_001360014
NP_001007189; NP_001129501; NP_001229825; NP_001229826; NP_055477;
	NP_001350781; NP_001350783; NP_001351247; NP_001351248; NP_001351249; NP_001356830; NP_001356831; NP_001356832
NP_001020597; NP_001164038; NP_808454; NP_001346943; NP_001391242;
	NP_001391243; NP_001391244; NP_001391245; NP_001391246; NP_001391247; NP_001391248; NP_001391249; NP_001391261; NP_001391262; NP_001391263; NP_001391264; NP_001391265
	Wikidata
View/Edit Human	View/Edit Mouse

DEPDC5 (or DEP domain-containing 5) is a human protein of poorly understood function but has been associated with cancer in several studies. It is encoded by a gene of the same name, located on chromosome 22.