DDOST

DDOST
Identifiers
Aliases	DDOST, AGER1, CDG1R, OKSWcl45, OST, OST48, WBP1, dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit, GATD6
External IDs	OMIM: 602202; MGI: 1194508; HomoloGene: 3821; GeneCards: DDOST; OMA:DDOST - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	20,661,544 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	138,039,939 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; stromal cell of endometrium; ; body of pancreas; ; caput epididymis; ; islet of Langerhans; ; rectum; ; smooth muscle tissue; ; placenta; ; beta cell; ; spleen;
	Top expressed in
	parotid gland; ; lacrimal gland; ; seminal vesicula; ; gastrula; ; dermis; ; islet of Langerhans; ; molar; ; stroma of bone marrow; ; vestibular sensory epithelium; ; crypt of lieberkuhn of small intestine;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	dolichyl-diphosphooligosaccharide-protein glycotransferase activity; protein binding; oligosaccharyl transferase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; endoplasmic reticulum; oligosaccharyltransferase complex; plasma membrane; azurophil granule membrane; protein-containing complex;
Biological process	response to cytokine; protein N-linked glycosylation via asparagine; protein glycosylation; protein N-linked glycosylation; T cell activation; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	1650
	13200
	ENSG00000244038
	ENSMUSG00000028757
	P39656
	O54734
	NM_005216
	NM_007838
	NP_005207
	NP_031864
	Wikidata
View/Edit Human	View/Edit Mouse

Dolichyl-diphosphooligosaccharide—protein glycosyltransferase 48 kDa subunit is an enzyme that in humans is encoded by the DDOST gene.

This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia.