Dopachrome tautomerase

DCT
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4HX1
Identifiers
Aliases	DCT, TRP-2, TYRP2, dopachrome tautomerase, OCA8
External IDs	OMIM: 191275; MGI: 102563; HomoloGene: 1447; GeneCards: DCT; OMA:DCT - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	94,479,682 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	118,289,656 bp
RNA expression pattern
	Top expressed in
	skin of thigh; ; skin of arm; ; secondary oocyte; ; nipple; ; skin of hip; ; vulva; ; human penis; ; retinal pigment epithelium; ; testicle; ; skin of abdomen;
	Top expressed in
	iris; ; ciliary body; ; stria vascularis; ; hair follicle; ; retinal pigment epithelium; ; utricle; ; epithelium of lens; ; corneal stroma; ; skin of back; ; left lobe of liver;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	isomerase activity; metal ion binding; oxidoreductase activity; copper ion binding; dopachrome isomerase activity;
Cellular component	cytoplasm; integral component of membrane; cytosol; membrane; melanosome; melanosome membrane;
Biological process	positive regulation of neuroblast proliferation; melanin biosynthetic process; cell development; ventricular zone neuroblast division; melanin biosynthetic process from tyrosine; epidermis development; developmental pigmentation; pigmentation; metabolism;
	Sources:Amigo / QuickGO
Orthologs
	1638
	13190
	ENSG00000080166
	ENSMUSG00000022129
	P40126
	P29812
NM_001129889; NM_001922; NM_001322182; NM_001322183; NM_001322184;
	NM_001322185; NM_001322186
	NM_010024
NP_001123361; NP_001309111; NP_001309112; NP_001309113; NP_001309114;
	NP_001309115; NP_001913
	NP_034154
	Wikidata
View/Edit Human	View/Edit Mouse

Dopachrome tautomerase (dopachrome delta-isomerase, tyrosinase-related protein 2), also known as DCT, is a human gene. Its expression is regulated by the microphthalmia-associated transcription factor (MITF).