Chichibabin pyridine synthesis

Chichibabin pyridine synthesis
Named after Aleksei Chichibabin
Reaction type Ring forming reaction
Identifiers
RSC ontology ID RXNO:0000526

The Chichibabin pyridine synthesis (/ˈtʃiːtʃiːˌbeɪbiːn/) is a method for synthesizing pyridine rings. The reaction involves the condensation reaction of aldehydes, ketones, α,β-unsaturated carbonyl compounds, or any combination of the above, with ammonia. It was reported by Aleksei Chichibabin in 1924. Methyl-substituted pyridines, which show widespread uses among multiple fields of applied chemistry, are prepared by this methodology.

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