Carbohydrate-responsive element-binding protein

MLXIPL
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4GNT
Identifiers
Aliases	MLXIPL, CHREBP, MIO, MONDOB, WBSCR14, WS-bHLH, bHLHd14, MLX interacting protein like, MLX
External IDs	OMIM: 605678; MGI: 1927999; HomoloGene: 32507; GeneCards: MLXIPL; OMA:MLXIPL - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	73,624,543 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	135,167,236 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; left adrenal cortex; ; right adrenal gland; ; right adrenal cortex; ; right hemisphere of cerebellum; ; subcutaneous adipose tissue; ; gastric mucosa; ; gastrocnemius muscle; ; right testis; ; muscle of thigh;
	Top expressed in
	crypt of lieberkuhn of small intestine; ; left lobe of liver; ; brown adipose tissue; ; islet of Langerhans; ; muscle of thigh; ; proximal tubule; ; zygote; ; soleus muscle; ; right kidney; ; skeletal muscle tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	carbohydrate response element binding; DNA binding; protein dimerization activity; protein homodimerization activity; DNA-binding transcription factor activity; transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein heterodimerization activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	transcription regulator complex; nucleoplasm; nucleus; cytoplasm; cytosol;
Biological process	intracellular signal transduction; positive regulation of lipid biosynthetic process; regulation of transcription, DNA-templated; glucose homeostasis; regulation of transcription by RNA polymerase II; anatomical structure morphogenesis; negative regulation of transcription by RNA polymerase II; positive regulation of fatty acid biosynthetic process; transcription, DNA-templated; positive regulation of transcription, DNA-templated; fatty acid homeostasis; positive regulation of cell population proliferation; negative regulation of peptidyl-serine phosphorylation; glucose mediated signaling pathway; negative regulation of oxidative phosphorylation; negative regulation of transcription, DNA-templated; positive regulation of glycolytic process; triglyceride homeostasis; positive regulation of transcription by RNA polymerase II; cellular response to carbohydrate stimulus; energy homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	51085
	58805
	ENSG00000009950
	ENSMUSG00000005373
	Q9NP71
	Q99MZ3
	NM_032951; NM_032952; NM_032953; NM_032954; NM_032994
	NM_021455; NM_001359237
	NP_116569; NP_116570; NP_116571; NP_116572
	NP_067430; NP_001346166
	Wikidata
View/Edit Human	View/Edit Mouse

Carbohydrate-responsive element-binding protein (ChREBP) also known as MLX-interacting protein-like (MLXIPL) is a protein that in humans is encoded by the MLXIPL gene. The protein name derives from the protein's interaction with carbohydrate response element sequences of DNA.