Calcium/calmodulin-dependent protein kinase type II subunit alpha

CAMK2A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2VZ6, 3SOA, 5IG3
Identifiers
Aliases	CAMK2A, CAMKA, calcium/calmodulin dependent protein kinase II alpha, MRD53, CaMKIINalpha, MRT63, CaMKIIalpha
External IDs	OMIM: 114078; MGI: 88256; HomoloGene: 56577; GeneCards: CAMK2A; OMA:CAMK2A - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	150,290,093 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	61,121,224 bp
RNA expression pattern
	Top expressed in
	Amygdala; ; prefrontal cortex; ; right frontal lobe; ; Region I of hippocampus proper; ; Brodmann area 9; ; cingulate gyrus; ; anterior cingulate cortex; ; frontal pole; ; orbitofrontal cortex; ; Brodmann area 46;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; lateral septal nucleus; ; olfactory tubercle; ; muscle of thigh; ; anterior amygdaloid area; ; piriform cortex; ; subiculum; ; primary visual cortex; ; perirhinal cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; protein homodimerization activity; kinase activity; protein binding; glutamate receptor binding; ATP binding; metal ion binding; protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity; calcium-dependent protein serine/threonine kinase activity; identical protein binding;
Cellular component	endocytic vesicle membrane; cytosol; membrane; plasma membrane; synapse; nucleoplasm; cell junction; presynaptic membrane; nucleus; cytoplasm; mitochondrion; postsynaptic density; neuron projection; calcium- and calmodulin-dependent protein kinase complex; dendrite; cell projection; dendritic spine; postsynaptic membrane; Schaffer collateral - CA1 synapse;
Biological process	phosphorylation; interferon-gamma-mediated signaling pathway; G1 phase; angiotensin-activated signaling pathway; positive regulation of cardiac muscle cell apoptotic process; regulation of neurotransmitter secretion; regulation of mitochondrial membrane permeability involved in apoptotic process; MAPK cascade; response to ischemia; positive regulation of NF-kappaB transcription factor activity; regulation of cellular response to heat; regulation of neuronal synaptic plasticity; protein autophosphorylation; calcium ion transport; positive regulation of calcium ion transport; dendrite morphogenesis; Wnt signaling pathway, calcium modulating pathway; nervous system development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; cell differentiation; intracellular signal transduction; protein phosphorylation; G1/S transition of mitotic cell cycle; dendritic spine development; regulation of synaptic vesicle docking; peptidyl-threonine autophosphorylation; regulation of neuron migration;
	Sources:Amigo / QuickGO
Orthologs
	815
	12322
	ENSG00000070808
	ENSMUSG00000024617
	Q9UQM7
	P11798
	NM_171825; NM_015981; NM_001363989; NM_001363990; NM_001369025
	NM_001286809; NM_009792; NM_177407
	NP_057065; NP_741960; NP_001350918; NP_001350919; NP_001355954
	NP_001273738; NP_033922; NP_803126; NP_001390238; NP_001390241
	Wikidata
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Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMKIIα), a.k.a. Ca²⁺/calmodulin-dependent protein kinase II alpha, is one subunit of CamKII, a protein kinase (i.e., an enzyme which phosphorylates proteins) that in humans is encoded by the CAMK2A gene.