Cathepsin S

CTSS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1GLO, 1MS6, 1NPZ, 1NQC, 2C0Y, 2F1G, 2FQ9, 2FRA, 2FRQ, 2FT2, 2FUD, 2FYE, 2G6D, 2G7Y, 2H7J, 2HH5, 2HHN, 2HXZ, 2OP3, 2R9M, 2R9N, 2R9O, 3IEJ, 3KWN, 3MPE, 3MPF, 3N3G, 3N4C, 3OVX, 4P6E, 4P6G
Identifiers
Aliases	CTSS, cathepsin S
External IDs	OMIM: 116845; MGI: 107341; HomoloGene: 20867; GeneCards: CTSS; OMA:CTSS - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	150,765,957 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	95,463,714 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; blood; ; rectum; ; bone marrow cells; ; gallbladder; ; mucosa of sigmoid colon; ; appendix; ; epithelium of colon; ; trabecular bone;
	Top expressed in
	stroma of bone marrow; ; mesenteric lymph nodes; ; calvaria; ; left colon; ; spleen; ; right lung lobe; ; ileum; ; globus pallidus; ; submandibular gland; ; median eminence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	fibronectin binding; cysteine-type peptidase activity; collagen binding; peptidase activity; cysteine-type endopeptidase activity; laminin binding; hydrolase activity; proteoglycan binding; serine-type endopeptidase activity;
Cellular component	intracellular membrane-bounded organelle; extracellular region; endolysosome lumen; lysosomal lumen; lysosome; extracellular space; tertiary granule lumen; ficolin-1-rich granule lumen; collagen-containing extracellular matrix; late endosome;
Biological process	positive regulation of cation channel activity; antigen processing and presentation; adaptive immune response; antigen processing and presentation of exogenous peptide antigen via MHC class II; protein processing; extracellular matrix disassembly; proteolysis; toll-like receptor signaling pathway; antigen processing and presentation of peptide antigen; immune response; cellular response to thyroid hormone stimulus; collagen catabolic process; proteolysis involved in cellular protein catabolic process; basement membrane disassembly; response to acidic pH; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	1520
	13040
	ENSG00000163131
	ENSMUSG00000038642
	P25774
	O70370
	NM_004079; NM_001199739
	NM_001267695; NM_021281
	NP_001186668; NP_004070
	NP_001254624; NP_067256
	Wikidata
View/Edit Human	View/Edit Mouse

Cathepsin S is a protein that in humans is encoded by the CTSS gene. Transcript variants utilizing alternative polyadenylation signals exist for this gene.

Cathepsin S is a member of the peptidase C1 family of cysteine cathepsins, a lysosomal cysteine protease that may participate in the degradation of antigenic proteins to peptides for presentation to the MHC class II. Cathepsin S can function as an elastase over a broad pH range in alveolar macrophages.