Adapter molecule crk

CRK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JU5, 2DVJ, 2EYV, 2EYW, 2EYX, 2EYY, 2EYZ, 2MS4
Identifiers
Aliases	CRK, CRKII, p38, v-crk avian sarcoma virus CT10 oncogene homolog, CRK proto-oncogene, adaptor protein
External IDs	OMIM: 164762; MGI: 88508; HomoloGene: 81850; GeneCards: CRK; OMA:CRK - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	1,463,162 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	75,597,734 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; mucosa of sigmoid colon; ; pericardium; ; lower lobe of lung; ; trigeminal ganglion; ; Pons; ; corpus epididymis; ; body of tongue; ; Achilles tendon; ; seminal vesicula;
	Top expressed in
	atrioventricular valve; ; Gonadal ridge; ; ureter; ; seminal vesicula; ; atrium; ; epithelium of stomach; ; decidua; ; parotid gland; ; lateral septal nucleus; ; primitive streak;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein-macromolecule adaptor activity; protein domain specific binding; ephrin receptor binding; protein binding; enzyme binding; insulin-like growth factor receptor binding; cytoskeletal protein binding; scaffold protein binding; phosphotyrosine residue binding; SH3 domain binding; SH2 domain binding; protein self-association; protein phosphorylated amino acid binding; protein tyrosine kinase binding;
Cellular component	cytoplasm; cytosol; membrane; plasma membrane; actin cytoskeleton; extracellular exosome; nucleus; membrane raft; protein-containing complex;
Biological process	Fc-gamma receptor signaling pathway involved in phagocytosis; regulation of GTPase activity; ephrin receptor signaling pathway; regulation of transcription by RNA polymerase II; regulation of Rac protein signal transduction; vascular endothelial growth factor receptor signaling pathway; regulation of actin cytoskeleton organization; positive regulation of substrate adhesion-dependent cell spreading; response to yeast; positive regulation of smooth muscle cell migration; response to hepatocyte growth factor; response to hydrogen peroxide; negative regulation of natural killer cell mediated cytotoxicity; cellular response to transforming growth factor beta stimulus; cellular response to nitric oxide; response to peptide; cellular response to nerve growth factor stimulus; cellular response to insulin-like growth factor stimulus; cellular response to endothelin; regulation of cell shape; regulation of signal transduction; positive regulation of cell growth; regulation of protein binding; regulation of wound healing; negative regulation of wound healing; response to cholecystokinin; regulation of cell motility; negative regulation of cell motility; neuron migration; regulation of leukocyte migration; lipid metabolism; dendrite development; cytokine-mediated signaling pathway; hippocampus development; cerebral cortex development; establishment of cell polarity; regulation of cell adhesion mediated by integrin; helper T cell diapedesis; reelin-mediated signaling pathway; regulation of dendrite development; cell chemotaxis; activation of GTPase activity; cerebellar neuron development; regulation of T cell migration;
	Sources:Amigo / QuickGO
Orthologs
	1398
	12928
	ENSG00000167193
	ENSMUSG00000017776
	P46108
	Q64010
	NM_016823; NM_005206
	NM_001277219; NM_001277221; NM_133656
	NP_005197; NP_058431
	NP_001264148; NP_001264150; NP_598417
	Wikidata
View/Edit Human	View/Edit Mouse

Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene.

The CRK protein participates in the Reelin signaling cascade downstream of DAB1.