COX8A

COX8A
Identifiers
Aliases	COX8A, COX, COX8, COX8-2, COX8L, VIII, VIII-L, cytochrome c oxidase subunit 8A, MC4DN15
External IDs	OMIM: 123870; MGI: 105959; HomoloGene: 3006; GeneCards: COX8A; OMA:COX8A - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	63,976,543 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	7,194,981 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; mucosa of transverse colon; ; left ventricle; ; right auricle of heart; ; renal medulla; ; myocardium of left ventricle; ; gastrocnemius muscle; ; muscle of thigh; ; human kidney; ; right ventricle;
	Top expressed in
	right kidney; ; superior frontal gyrus; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; yolk sac; ; granulocyte; ; embryo; ; embryo; ; pyloric antrum;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; cytochrome-c oxidase activity;
Cellular component	integral component of membrane; mitochondrial inner membrane; mitochondrion; mitochondrial respiratory chain complex IV; membrane; respiratory chain complex IV;
Biological process	generation of precursor metabolites and energy; mitochondrial electron transport, cytochrome c to oxygen; proton transmembrane transport; electron transport chain;
	Sources:Amigo / QuickGO
Orthologs
	1351
	12868
	ENSG00000176340
	ENSMUSG00000035885
	P10176
	Q64445
	NM_004074
	NM_007750
	NP_004065
	NP_031776
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome c oxidase subunit 8A (COX8A) is a protein that in humans is encoded by the COX8A gene. Cytochrome c oxidase 8A is a subunit of the cytochrome c oxidase complex, also known as Complex IV. Mutations in the COX8A gene have been associated with complex IV deficiency with Leigh syndrome and epilepsy.