COX7A2

COX7A2
Identifiers
Aliases	COX7A2, COX7AL, COX7AL1, COXVIIAL, COXVIIa-L, VIIAL, cytochrome c oxidase subunit 7A2
External IDs	OMIM: 123996; MGI: 1316715; HomoloGene: 36082; GeneCards: COX7A2; OMA:COX7A2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	75,250,323 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	79,667,160 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; left testis; ; right testis; ; pancreatic ductal cell; ; right ventricle; ; Brodmann area 23; ; sperm; ; apex of heart; ; primary visual cortex; ; lateral nuclear group of thalamus;
	Top expressed in
	facial motor nucleus; ; medial ganglionic eminence; ; digastric muscle; ; otic placode; ; temporal muscle; ; sternocleidomastoid muscle; ; epithelium of stomach; ; triceps brachii muscle; ; intercostal muscle; ; medial vestibular nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	electron transfer activity; cytochrome-c oxidase activity;
Cellular component	mitochondrial inner membrane; membrane; mitochondrion; mitochondrial respirasome;
Biological process	proton transmembrane transport; electron transport chain; regulation of oxidative phosphorylation; mitochondrial respirasome assembly;
	Sources:Amigo / QuickGO
Orthologs
	1347
	12866
	ENSG00000112695
	ENSMUSG00000032330
	P14406
	P48771
	NM_001865
	NM_009945
	NP_001856; NP_001353221; NP_001353222
	NP_034075
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome c oxidase polypeptide 7A2, mitochondrial is an enzyme that in humans is encoded by the COX7A2 gene.

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen.

This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa and the polypeptide 2 is present in both muscle and nonmuscle tissues.

In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, present in all tissues. This gene may have several pseudogenes.