COX4I1

COX4I1
Identifiers
Aliases	COX4I1, COX4, COX4-1, COXIV, COX IV-1, COXIV-1, cytochrome c oxidase subunit 4I1, MC4DN16
External IDs	OMIM: 123864; MGI: 88473; HomoloGene: 37537; GeneCards: COX4I1; OMA:COX4I1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	85,807,068 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	121,400,946 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; left ventricle; ; right auricle of heart; ; right ventricle; ; prefrontal cortex; ; myocardium of left ventricle; ; middle temporal gyrus; ; right frontal lobe; ; Brodmann area 9; ; Brodmann area 23;
	Top expressed in
	myocardium of ventricle; ; right ventricle; ; Epithelium of choroid plexus; ; soleus muscle; ; extraocular muscle; ; epithelium of stomach; ; brown adipose tissue; ; transitional epithelium of urinary bladder; ; thoracic diaphragm; ; nucleus accumbens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; cytochrome-c oxidase activity;
Cellular component	mitochondrial inner membrane; extracellular exosome; membrane; mitochondrion; nucleus; mitochondrial membranes; mitochondrial respiratory chain complex IV; integral component of membrane;
Biological process	generation of precursor metabolites and energy; response to nutrient; proton transmembrane transport; mitochondrial electron transport, cytochrome c to oxygen; electron transport chain;
	Sources:Amigo / QuickGO
Orthologs
	1327
	12857
	ENSG00000131143
	ENSMUSG00000031818
	P13073; Q86WV2
	P19783
NM_001861; NM_001318786; NM_001318788; NM_001318794; NM_001318797;
	NM_001318802
	NM_001293559; NM_009941
NP_001305715; NP_001305717; NP_001305723; NP_001305726; NP_001305731;
	NP_001852; NP_001305715.1
	NP_001280488; NP_034071
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) is an enzyme that in humans is encoded by the COX4I1 gene. COX4I1 is a nuclear-encoded isoform of cytochrome c oxidase (COX) subunit 4. Cytochrome c oxidase (complex IV) is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane, acting as the terminal enzyme of the mitochondrial respiratory chain. Antibodies against COX4 can be used to identify the inner membrane of mitochondria in immunofluorescence studies. Mutations in COX4I1 have been associated with COX deficiency and Fanconi anemia.