CASPR

CNTNAP1
Identifiers
Aliases	CNTNAP1, CASPR, CNTNAP, NRXN4, P190, contactin associated protein 1, CHN3
External IDs	OMIM: 602346; MGI: 1858201; HomoloGene: 2693; GeneCards: CNTNAP1; OMA:CNTNAP1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	42,699,993 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	101,081,550 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; Region I of hippocampus proper; ; postcentral gyrus; ; right frontal lobe; ; Brodmann area 46; ; superior frontal gyrus; ; orbitofrontal cortex; ; lateral nuclear group of thalamus; ; prefrontal cortex; ; Brodmann area 9;
	Top expressed in
	superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; cerebellar cortex; ; neural layer of retina; ; zygote; ; lumbar subsegment of spinal cord; ; perirhinal cortex; ; secondary oocyte; ; entorhinal cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	SH3 domain binding; protein binding; signaling receptor activity;
Cellular component	integral component of membrane; membrane; myelin sheath; voltage-gated potassium channel complex; integral component of plasma membrane; axon; paranode region of axon; cell junction; paranodal junction; presynaptic active zone membrane;
Biological process	neuromuscular process controlling posture; neuromuscular process controlling balance; protein localization to paranode region of axon; cell adhesion; cytoskeleton organization; neuronal action potential propagation; neuron projection development; signal transduction; positive regulation of signal transduction; central nervous system myelination; myelination in peripheral nervous system; paranodal junction assembly; neuron projection morphogenesis; protein localization to juxtaparanode region of axon;
	Sources:Amigo / QuickGO
Orthologs
	8506
	53321
	ENSG00000108797
	ENSMUSG00000017167
	P78357
	O54991
	NM_003632
	NM_016782
	NP_003623
	NP_058062
	Wikidata
View/Edit Human	View/Edit Mouse

CASPR also known as Contactin associated protein 1, Paranodin and CASPR1 is a protein that in humans is encoded by the CNTNAP1 gene. CASPR is a part of the neurexin family of proteins, hence its another name "Neurexin IV". CASPR is a membrane protein found in the neuronal membrane in the paranodal section of the axon[[]] in myelinated neurons, between the Nodes of Ranvier containing Na+ channels, and juxtaparanode, which contains K+ channels. During myelination, caspr associates with contactin in a cis complex, though its precise role in myelination is not yet understood.