Cyclic nucleotide-gated channel alpha 1

CNGA1
Identifiers
Aliases	CNGA1, CNCG, CNCG1, CNG-1, CNG1, RCNC1, RCNCa, RCNCalpha, RP49, Cyclic nucleotide-gated channel alpha 1, cyclic nucleotide gated channel alpha 1, cyclic nucleotide gated channel subunit alpha 1
External IDs	OMIM: 123825; MGI: 88436; HomoloGene: 55432; GeneCards: CNGA1; OMA:CNGA1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	48,016,681 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	72,801,618 bp
RNA expression pattern
	Top expressed in
	amniotic fluid; ; right lobe of liver; ; sural nerve; ; pancreatic epithelial cell; ; testicle; ; pancreatic ductal cell; ; mucosa of urinary bladder; ; skin of abdomen; ; skin of hip; ; corpus epididymis;
	Top expressed in
	neural layer of retina; ; retinal pigment epithelium; ; epithelium of lens; ; ciliary body; ; iris; ; thymus; ; corneal stroma; ; zygote; ; conjunctival fornix; ; secondary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; intracellular cyclic nucleotide activated cation channel activity; ion channel activity; protein binding; voltage-gated potassium channel activity; cGMP binding; intracellular cAMP-activated cation channel activity; intracellular cGMP-activated cation channel activity;
Cellular component	integral component of membrane; membrane; plasma membrane; photoreceptor outer segment; integral component of plasma membrane; photoreceptor outer segment membrane;
Biological process	response to stimulus; regulation of rhodopsin mediated signaling pathway; regulation of membrane potential; ion transport; cation transmembrane transport; transmembrane transport; visual perception; rhodopsin mediated signaling pathway; potassium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	1259
	12788
	ENSG00000198515
	ENSMUSG00000067220
	P29973
	P29974
	NM_000087; NM_001142564; NM_001379270
	NM_007723
	NP_000078; NP_001136036; NP_001366199; NP_000078.2
	NP_031749
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclic nucleotide-gated channel alpha 1, also known as CNGA1, is a human gene encoding an ion channel protein. Heterologously expressed CNGA1 can form a functional channel that is permeable to calcium. In rod photoreceptors, however, CNGA1 forms a heterotetramer with CNGB1 in a 3:1 ratio. The addition of the CNGB1 channel imparts altered properties including more rapid channel kinetics and greater cAMP-activated current. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/B1 channels and, therefore, hyperpolarization of the membrane potential.