CLEC1B

CLEC1B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2C6U, 3WSR, 3WWK
Identifiers
Aliases	CLEC1B, 1810061I13Rik, CLEC2, CLEC2B, PRO1384, QDED721, C-type lectin domain family 1 member B
External IDs	OMIM: 606783; MGI: 1913287; HomoloGene: 49468; GeneCards: CLEC1B; OMA:CLEC1B - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	10,013,424 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	129,386,298 bp
RNA expression pattern
	Top expressed in
	monocyte; ; testicle; ; liver; ; right lobe of liver; ; granulocyte; ; trabecular bone; ; blood; ; bone marrow; ; buccal mucosa cell; ; bone marrow cells;
	Top expressed in
	blood; ; tibiofemoral joint; ; spleen; ; mesenteric lymph nodes; ; granulocyte; ; hepatobiliary system; ; liver; ; embryo; ; right lung; ; right lung lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; carbohydrate binding; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	platelet activation; defense response; cell surface receptor signaling pathway; platelet formation; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	51266
	56760
	ENSG00000165682
	ENSMUSG00000030159
	Q9P126
	Q9JL99
	NM_001099431; NM_016509; NM_001393342
	NM_001204239; NM_001204253; NM_019985
	NP_001092901; NP_057593
	NP_001191168; NP_001191182; NP_064369
	Wikidata
View/Edit Human	View/Edit Mouse

C-type lectin domain family 1 member B (i.e., CLEC-1b), also termed C-type lectin-like receptor 2 (i.e., CLEC-2), is a protein that in humans is encoded by the CLEC1B gene.

Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells.[supplied by OMIM]