CLEC10A

CLEC10A
Identifiers
Aliases	CLEC10A, CD301, CLECSF13, CLECSF14, HML, HML2, MGL, C-type lectin domain family 10 member A, C-type lectin domain containing 10A
External IDs	OMIM: 605999; MGI: 96975; HomoloGene: 7836; GeneCards: CLEC10A; OMA:CLEC10A - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	7,080,307 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	70,061,660 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; granulocyte; ; monocyte; ; right coronary artery; ; gallbladder; ; appendix; ; rectum; ; lymph node; ; testicle;
	Top expressed in
	stroma of bone marrow; ; white adipose tissue; ; skin of external ear; ; subcutaneous adipose tissue; ; tunica adventitia of aorta; ; mammary gland; ; lip; ; primary oocyte; ; muscle of thigh; ; sciatic nerve;
	More reference expression data
	n/a
Gene ontology
Molecular function	carbohydrate binding;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	innate immune response; endocytosis; adaptive immune response; immune system process; stimulatory C-type lectin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	10462
	17312
	ENSG00000132514
	ENSMUSG00000000318
	Q8IUN9
	P49300
	NM_006344; NM_182906; NM_001330070
	NM_001204252; NM_010796
	NP_001316999; NP_006335; NP_878910
	NP_001191181; NP_034926
	Wikidata
View/Edit Human	View/Edit Mouse

C-type lectin domain family 10 member A (CLEC10A) also designated as CD301 is a protein that in humans is encoded by the CLEC10A gene. CLEC10A is part of the C-type lectin superfamily and binds to N-Acetylgalactosamine (GalNAc). It is mainly expressed on myeloid cells and also on oocytes and very early stages of embryogenesis. CLEC10A is used as a marker of the CD1c⁺ dendritic cell subgroup, also called cDC2. The actions of CLEC10A are diverse, depending on the ligand and environment.