CLCA1

CLCA1
Identifiers
Aliases	CLCA1, CACC, CACC1, CLCRG1, CaCC-1, GOB5, hhCaCC-1, chloride channel accessory 1
External IDs	OMIM: 603906; MGI: 1346342; HomoloGene: 984; GeneCards: CLCA1; OMA:CLCA1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	86,500,259 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	144,738,537 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; mucosa of sigmoid colon; ; jejunal mucosa; ; mucosa of transverse colon; ; rectum; ; duodenum; ; cecum; ; appendix; ; pancreatic ductal cell; ; epithelium of colon;
	Top expressed in
	left colon; ; intestinal villus; ; cervix; ; pyloric antrum; ; ileum; ; duodenum; ; mucous cell of stomach; ; crypt of lieberkuhn of small intestine; ; epithelium of small intestine; ; jejunum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; peptidase activity; hydrolase activity; chloride channel activity; metallopeptidase activity; metalloendopeptidase activity; intracellular calcium activated chloride channel activity;
Cellular component	extracellular region; integral component of membrane; integral component of plasma membrane; microvillus; zymogen granule membrane; membrane; plasma membrane; secretory granule; extracellular space;
Biological process	calcium ion transport; proteolysis; chloride transport; ion transport; ion transmembrane transport; cellular response to hypoxia; chloride transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	1179
	23844
	ENSG00000016490
	ENSMUSG00000028255
	A8K7I4
	Q9D7Z6
	NM_001285
	NM_017474
	NP_001276
	NP_059502
	Wikidata
View/Edit Human	View/Edit Mouse

Chloride channel accessory 1 is a protein that in humans is encoded by the CLCA1 gene.

This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine. Protein structure prediction methods suggest the N-terminal region of CLCA1 protein is a zinc metalloprotease.