CISH (protein)

CISH
Identifiers
Aliases	CISH, BACTS2, CIS, CIS-1, G18, SOCS, cytokine inducible SH2 containing protein
External IDs	OMIM: 602441; MGI: 103159; HomoloGene: 7667; GeneCards: CISH; OMA:CISH - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	50,611,774 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	107,179,983 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; human kidney; ; tibialis anterior muscle; ; right lobe of liver; ; upper lobe of left lung; ; blood; ; placenta; ; apex of heart;
	Top expressed in
	interventricular septum; ; triceps brachii muscle; ; sternocleidomastoid muscle; ; temporal muscle; ; myocardium of ventricle; ; digastric muscle; ; cardiac muscles; ; choroid plexus of fourth ventricle; ; right ventricle; ; right kidney;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein kinase inhibitor activity; protein binding; molecular function; 1-phosphatidylinositol-3-kinase regulator activity;
Cellular component	cytoplasm; cytosol; plasma membrane; cellular component; phosphatidylinositol 3-kinase complex;
Biological process	regulation of growth; negative regulation of insulin receptor signaling pathway; protein kinase C-activating G protein-coupled receptor signaling pathway; intracellular signal transduction; negative regulation of signal transduction; regulation of cell growth; protein ubiquitination; negative regulation of protein kinase activity; negative regulation of receptor signaling pathway via JAK-STAT; cytokine-mediated signaling pathway; post-translational protein modification; interleukin-7-mediated signaling pathway; regulation of phosphatidylinositol 3-kinase activity; phosphatidylinositol phosphate biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	1154
	12700
	ENSG00000114737
	ENSMUSG00000032578
	Q9NSE2
	Q62225
	NM_013324; NM_145071
	NM_009895; NM_001317354
	NP_037456; NP_659508
	NP_001304283; NP_034025
	Wikidata
View/Edit Human	View/Edit Mouse

Cytokine-inducible SH2-containing protein is a protein that in humans is encoded by the CISH gene. CISH orthologs have been identified in most mammals with sequenced genomes. CISH controls T cell receptor (TCR) signaling, and variations of CISH with certain SNPs are associated with susceptibility to bacteremia, tuberculosis and malaria.