CHKB (gene)

CHKB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3FEG, 2IG7, 3LQ3
Identifiers
Aliases	CHKB, CHETK, CHKL, CK, CKB, CKEKB, EK, EKB, MDCMC, choline kinase beta
External IDs	OMIM: 612395; MGI: 1328313; HomoloGene: 88718; GeneCards: CHKB; OMA:CHKB - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	50,601,455 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	89,314,111 bp
RNA expression pattern
	Top expressed in
	pituitary gland; ; granulocyte; ; anterior pituitary; ; spleen; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; right hemisphere of cerebellum; ; right uterine tube; ; apex of heart; ; gastric mucosa;
	Top expressed in
	islet of Langerhans; ; bone marrow; ; colon; ; duodenum; ; jejunum; ; granulocyte; ; spleen; ; ileum; ; zone of skin; ; cerebellar cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; ATP binding; kinase activity; choline kinase activity; ethanolamine kinase activity;
Cellular component	cytosol;
Biological process	phosphatidylcholine biosynthetic process; phosphatidylethanolamine biosynthetic process; phosphorylation; lipid metabolism; phospholipid biosynthetic process; glycerophospholipid biosynthetic process; CDP-choline pathway;
	Sources:Amigo / QuickGO
Orthologs
	1120
	12651
	ENSG00000100288
	ENSMUSG00000022617
	Q9Y259
	O55229
	NM_152253; NM_005198
	NM_007692
	NP_005189
	NP_031718
	Wikidata
View/Edit Human	View/Edit Mouse

Choline kinase beta (CK), also known as Ethanolamine kinase (EK), Choline kinase-like protein , choline/ethanolamine kinase beta (CKEKB), or Choline/ethanolamine kinase is a protein encoded by the CHKB gene. This gene is found on chromosome 22 in humans. The encoded protein plays a key role in phospholipid biosynthesis. Choline kinase (CK) and ethanolamine kinase (EK) catalyzes the first step in phosphatidylethanolamine biosynthesis. Read-through transcripts are expressed from this locus that include exons from the downstream CPT1B locus.