Carboxylesterase 2

CES2
Identifiers
Aliases	CES2, CE-2, CES2A1, PCE-2, iCE, Carboxylesterase 2, CES-2
External IDs	OMIM: 605278; MGI: 3648740; HomoloGene: 128645; GeneCards: CES2; OMA:CES2 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	66,945,096 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	105,747,810 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; mucosa of ileum; ; mucosa of colon; ; mucosa of sigmoid colon; ; duodenum; ; mucosa of transverse colon; ; mucosa of pharynx; ; rectum; ; right lobe of liver; ; kidney tubule;
	Top expressed in
	proximal tubule; ; human kidney; ; right kidney; ; duodenum; ; jejunum; ; liver; ; colon; ; testicle; ; islet of Langerhans;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	methylumbelliferyl-acetate deacetylase activity; hydrolase activity; carboxylic ester hydrolase activity; methyl indole-3-acetate esterase activity;
Cellular component	endoplasmic reticulum lumen; endoplasmic reticulum; extracellular space;
Biological process	xenobiotic metabolic process; catabolic process; prostaglandin metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	8824
	436059
	ENSG00000172831
	ENSMUSG00000091813
	O00748
	F6Z9B9
NM_003869; NM_198061; NM_001365405; NM_001365406; NM_001365407;
	NM_001365408
	NM_001272045
NP_003860; NP_932327; NP_001352334; NP_001352335; NP_001352336;
	NP_001352337
	NP_001258974
	Wikidata
View/Edit Human	View/Edit Mouse

Carboxylesterase 2 is an enzyme that in humans is encoded by the CES2 gene. It is a member of the alpha/beta fold hydrolase family.

Carboxylesterase 2 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters. The specific function of this enzyme has not yet been determined; however, it is speculated that carboxylesterases may play a role in lipid metabolism and/or the blood–brain barrier system. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.