CEMIP

CEMIP
Identifiers
Aliases	CEMIP, CCSP1, KIAA1199, TMEM2L, HYBID, cell migration inducing hyaluronan binding protein, cell migration inducing hyaluronidase 1
External IDs	OMIM: 608366; MGI: 2443629; HomoloGene: 10268; GeneCards: CEMIP; OMA:CEMIP - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	80,951,776 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	83,735,710 bp
RNA expression pattern
	Top expressed in
	Epithelium of choroid plexus; ; trigeminal ganglion; ; stromal cell of endometrium; ; tibia; ; pericardium; ; cartilage tissue; ; olfactory bulb; ; lymph node; ; right lobe of thyroid gland; ; left lobe of thyroid gland;
	Top expressed in
	calvaria; ; vestibular sensory epithelium; ; cranial dura mater; ; stroma of bone marrow; ; body of femur; ; vestibular membrane of cochlear duct; ; stria vascularis; ; trigeminal ganglion; ; gastrula; ; lumbar spinal ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	clathrin heavy chain binding; ER retention sequence binding; hydrolase activity, acting on glycosyl bonds; protein binding; hyaluronic acid binding; hydrolase activity; hyalurononglucosaminidase activity;
Cellular component	cytoplasm; membrane; plasma membrane; extracellular region; endoplasmic reticulum; clathrin-coated pit; nucleus; clathrin-coated vesicle membrane; clathrin-coated endocytic vesicle;
Biological process	hyaluronan biosynthetic process; hyaluronan catabolic process; positive regulation of cell migration; positive regulation of protein kinase C activity; positive regulation of release of sequestered calcium ion into cytosol; hearing; positive regulation of peptidyl-threonine phosphorylation; metabolism; positive regulation of protein targeting to membrane;
	Sources:Amigo / QuickGO
Orthologs
	57214
	80982
	ENSG00000103888
	ENSMUSG00000052353
	Q8WUJ3
	Q8BI06
	NM_018689; NM_001293298; NM_001293304
	NM_030728
	NP_001280227; NP_001280233; NP_061159
	NP_109653
	Wikidata
View/Edit Human	View/Edit Mouse

Cell migration-inducing and hyaluronan-binding protein (CEMIP), formerly known as KIAA1199, is a protein that in humans is encoded by the CEMIP gene. CEMIP has been shown to bind hyaluronic acid and catalyze its depolymerization independently of CD44 and hyaluronidases. Such function has also been validated in mice.

CEMIP is associated with nonsyndromic deafness, as well as a variety of cancers.