Insulin-like growth factor 2 receptor

IGF2R
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1E6F, 1GP0, 1GP3, 1GQB, 1JPL, 1JWG, 1LF8, 2CNJ, 2V5N, 2V5O, 2V5P, 2L29, 2L2A, 2M68, 5IEI, 2M6T
Identifiers
Aliases	IGF2R, CD222, CIMPR, M6P-R, MPR1, MPRI, M6P/MPR 300, CI-M6PR, MPR300, insulin like growth factor 2 receptor
External IDs	OMIM: 147280; MGI: 96435; HomoloGene: 676; GeneCards: IGF2R; OMA:IGF2R - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	160,113,507 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	12,988,551 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; gastrocnemius muscle; ; granulocyte; ; blood; ; muscle of thigh; ; tibialis anterior muscle; ; monocyte; ; spleen; ; upper lobe of left lung; ; right adrenal cortex;
	Top expressed in
	atrium; ; umbilical cord; ; atrioventricular valve; ; internal carotid artery; ; endocardial cushion; ; lacrimal gland; ; epithelium of small intestine; ; human fetus; ; left lung lobe; ; Ileal epithelium;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	retinoic acid binding; insulin-like growth factor binding; G protein-coupled receptor activity; transporter activity; phosphoprotein binding; insulin-like growth factor-activated receptor activity; insulin-like growth factor II binding; mannose binding; identical protein binding; enzyme binding; G-protein alpha-subunit binding; protein binding; kringle domain binding; signaling receptor activity;
Cellular component	cytoplasm; integral component of membrane; endosome; late endosome; membrane; focal adhesion; clathrin coat; endocytic vesicle; integral component of plasma membrane; cell surface; lysosomal membrane; trans-Golgi network; early endosome; nuclear envelope lumen; perinuclear region of cytoplasm; trans-Golgi network transport vesicle; lysosome; extracellular exosome; nucleus; trans-Golgi network membrane; transport vesicle; extracellular space; Golgi apparatus; plasma membrane; clathrin-coated vesicle membrane; secretory granule membrane; clathrin-coated vesicle;
Biological process	regulation of apoptotic process; G protein-coupled receptor signaling pathway; response to retinoic acid; post-embryonic development; receptor-mediated endocytosis; animal organ regeneration; spermatogenesis; positive regulation of apoptotic process; liver development; signal transduction; insulin-like growth factor receptor signaling pathway; neutrophil degranulation; membrane organization; transport; post-Golgi vesicle-mediated transport; lysosomal transport;
	Sources:Amigo / QuickGO
Orthologs
	3482
	16004
	ENSG00000197081
	ENSMUSG00000023830
	P11717
	Q07113
	NM_000876
	NM_010515
	NP_000867
	NP_034645
	Wikidata
View/Edit Human	View/Edit Mouse

Insulin-like growth factor 2 receptor (IGF2R), also called the cation-independent mannose-6-phosphate receptor (CI-MPR) is a protein that in humans is encoded by the IGF2R gene. IGF2R is a multifunctional protein receptor that binds insulin-like growth factor 2 (IGF2) at the cell surface and mannose-6-phosphate (M6P)-tagged proteins in the trans-Golgi network.